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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
35.76
Human Site:
Y19
Identified Species:
56.19
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
Y19
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Chimpanzee
Pan troglodytes
XP_514178
522
59597
Y96
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
Y19
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Dog
Lupus familis
XP_537144
668
75595
Y243
H
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
Y19
H
S
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Rat
Rattus norvegicus
XP_001055166
443
51340
Y19
H
S
I
G
T
G
S
Y
G
R
C
Q
K
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
N73
T
E
F
S
D
G
F
N
T
W
P
L
P
S
K
Chicken
Gallus gallus
NP_001026221
444
51581
Y19
L
T
I
G
A
G
S
Y
G
K
C
R
K
V
R
Frog
Xenopus laevis
NP_001079490
442
52004
Y19
Y
T
I
G
S
G
S
Y
G
K
C
Q
K
I
R
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
L20
G
A
F
G
I
V
H
L
C
R
R
R
T
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
F30
A
V
M
G
N
G
S
F
G
T
C
Y
K
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
Y19
Y
T
I
G
S
G
S
Y
G
K
C
R
K
V
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
V21
S
F
G
S
A
L
L
V
R
H
K
H
E
K
K
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
F36
E
E
I
G
R
G
S
F
G
S
V
R
K
V
I
Red Bread Mold
Neurospora crassa
P48479
858
94329
G19
K
I
G
H
G
S
F
G
I
I
R
K
V
R
R
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
6.6
66.6
86.6
13.3
N.A.
46.6
N.A.
N.A.
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
86.6
100
20
N.A.
66.6
N.A.
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
0
40
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
60
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
14
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
67
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% D
% Glu:
7
14
0
0
0
0
0
0
0
0
0
0
7
0
0
% E
% Phe:
0
7
14
0
0
0
14
14
0
0
0
0
0
0
0
% F
% Gly:
7
0
14
80
7
80
0
7
74
0
0
0
0
0
0
% G
% His:
20
0
0
7
0
0
7
0
0
7
0
7
0
0
0
% H
% Ile:
0
7
67
0
7
0
0
0
7
7
0
0
0
47
7
% I
% Lys:
7
0
0
0
0
0
0
0
0
20
7
7
74
7
14
% K
% Leu:
7
0
0
0
0
7
7
7
0
0
0
7
0
0
0
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
47
0
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
7
47
14
27
0
7
74
% R
% Ser:
7
14
0
14
14
7
74
0
0
7
0
0
0
7
7
% S
% Thr:
7
47
0
0
40
0
0
0
7
7
0
0
7
0
0
% T
% Val:
0
7
0
0
0
7
0
7
0
0
7
0
7
27
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
34
0
0
0
0
0
0
60
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _